C18 Malignant neoplasm of colon
One study on Malignant neoplasm of colon is accessible to registered UDBN website users
Colorectal cancer case-control study 2000
UDBN partners:
Prof Harry Campbell (University of Edinburgh)
Prof Malcolm Dunlop (University of Edinburgh)
Dr Mary Porteous (University of Edinburgh)
Population-based DNA sample collections from colorectal cancer patients, close relatives and matched controls.
This collection comprises DNA and peripheral blood lymphocytes stored from 2500 cases of colorectal cancer. The cases were aged 16-79 years presenting to surgical units in Scottish hospitals with a confirmed diagnosis (including histological confirmation) of adenocarcinoma of colon or rectum. It also comprises 2500 population-based controls drawn from a population base register. It also includes DNA from 600 relatives of cases (including 126 “family sets” suitable for TDT analysis -2 parents; or 1 parent and 2 or more sibs; or 3 or more sibs). Participation rates (including obtaining blood) among those approached are approximately 58% for cases, 91% for relatives and 57% for population based controls. The accrual of incident cases was prospective and recruitment took place as soon as possible after diagnosis (typically within 2-3 months of diagnosis) so that unbiased investigation of genetic determinants of survival and treatment response can be made. Consent was obtained from all subjects in accordance with the recommended procedures laid out in the MRC document “Human tissue and biological samples for use in research” and covers medical genetic research.
Questionnaires on lifestyle and risk exposures were completed by 82% of cases and 97% of controls recruited. Other data collected include personal, demographic and clinical details. Further details can be obtained from the principal investigators.
To access individual data and samples, first register.
Colorectal cancer case-control study 2000
UDBN partners:
Prof Harry Campbell (University of Edinburgh)
Prof Malcolm Dunlop (University of Edinburgh)
Dr Mary Porteous (University of Edinburgh)
Population-based DNA sample collections from colorectal cancer patients, close relatives and matched controls.
This collection comprises DNA and peripheral blood lymphocytes stored from 2500 cases of colorectal cancer. The cases were aged 16-79 years presenting to surgical units in Scottish hospitals with a confirmed diagnosis (including histological confirmation) of adenocarcinoma of colon or rectum. It also comprises 2500 population-based controls drawn from a population base register. It also includes DNA from 600 relatives of cases (including 126 “family sets” suitable for TDT analysis -2 parents; or 1 parent and 2 or more sibs; or 3 or more sibs). Participation rates (including obtaining blood) among those approached are approximately 58% for cases, 91% for relatives and 57% for population based controls. The accrual of incident cases was prospective and recruitment took place as soon as possible after diagnosis (typically within 2-3 months of diagnosis) so that unbiased investigation of genetic determinants of survival and treatment response can be made. Consent was obtained from all subjects in accordance with the recommended procedures laid out in the MRC document “Human tissue and biological samples for use in research” and covers medical genetic research.
Questionnaires on lifestyle and risk exposures were completed by 82% of cases and 97% of controls recruited. Other data collected include personal, demographic and clinical details. Further details can be obtained from the principal investigators.
To access individual data and samples, first register.
