C92.0 Acute myeloid leukaemia
One study on Acute myeloid leukaemia is accessible to registered UDBN website users.
UDBN Partner:
Prof David Linch (University College London)
A leukaemic blast cell DNA and RNA collection has been initiated from adult patients with acute myeloid leukaemia at presentation. This will be maintained and extended to include relapse samples and diagnostic samples of acute lymphoblastic leukaemia. A particular focus will be on therapy related leukaemias and in these cases buccal scrapes will also be stored as a source of constitutive DNA. All samples are from patients entered into MRC trials: the leukaemia is fully characterized, clinical details recorded and responses to treatment and long-term follow up maintained. This thus provides a unique resource. Samples will be used to study the multi-step molecular pathogenesis of AML, enable prognostic stratification and improved treatment selection and hopefully the development of novel therapies. Genetic factors underlying susceptibility to leukaemia and response to treatment will be analysed. The findings will have broader significance to the regulation of haemopoiesis and to other forms of malignancy.
To access individual data and samples, first register.
