E00-E90 Endocrine, nutritional and metabolic diseases
One study in Endocrine, nutritional and metabolic diseases is accessible to registered UDBN website users
UDBN partners:
Prof A Hattersley (Exeter University)
Prof Mark McCarthy (Oxford University)
Type 2 diabetes affects over 150m people world-wide and the prevalence is increasing rapidly. It is a major cause of morbidity and mortality that accounts for approximately 5% of NHS expenditure in the UK. Despite its high prevalence and clinical importance its primary aetiology is still imperfectly understood. Twin, family, racial migration and genetic admixture studies all support genetic susceptibility as being important in the aetiology of type 2 diabetes. We propose to collect 500 parent offspring trios and 500 families with single parent and at least 2 additional siblings with type 2 diabetes as a resource for defining susceptibility genes. This will be complementary to a major UK collaborative initiative in defining these genes set up in 1996 by the British diabetes association and 6 major UK centres. This resource will be specifically used for defining the genes that lie within areas of linkage within the UK sibling pair collection. The 150 trios already collected have been in considerable demand by other researchers in the field and the establishment of cell lines will enable other scientists to work on these samples. This collection will give adequate power to define important susceptibility genes, which in turn will give new insight, and potential drug targets for treatment and possibly prevention of type 2 diabetes.
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