F00-F99 Mental and behavioural disorders
One study on Mental and behavioural disorders is accessible to registered UDBN website users.
UDBN partner:
Prof P McGuffin (Institute of Psychiatry London)
Unipolar is amongst the most common of psychiatric disorders with one week prevalence in the UK of over 2% and a lifetime risk of hospital treated disorder of 5-8% The World Bank's Global Burden of Disease study found that, in economic terms, the burden imposed by unipolar depression is only rivalled by that of cardiovascular disease. Family twin and adoption data provide a compelling case that major depression is strongly influenced by genes, but suggest that this is likely to be, as with other common conditions, the result of several, perhaps many genes of small effect. The DNA collection will be from subjects suffering from severe recurrent unipolar depressive disorder and ethnically matched controls screened for absence of psychiatric disorder. The depressed subjects will be over the age of 18 and will have had two or more episodes of depression as defined by the research criteria of ICD10 and by DSMIV. The sample size will allow sufficient power to detect or replicate associations with susceptibility loci of modest or small effect and will be suitable both for candidate gene studies and linkage disequilibrium mapping in genomic regions of interest identified by linkage studies.
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